Talk to your health care professional or pharmacist for more information. Fatigue (low energy) and nausea werent specifically reported as side effects in clinical trials of Prolia. While youre receiving Prolia treatment, your doctor will monitor your cholesterol levels with regular blood tests. In this article well discuss the uses, side effects, safety precautions, and other important information about Prolia. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are receiving this medicine. It is often used in osteoporosis. Drug class: Miscellaneous bone resorption inhibitors. But weight gain may be a symptom of a side effect called peripheral edema. But if youre planning to have surgery, you may need to take a break This is not a complete list of warnings for Prolia. You should also take calcium and vitamin D supplements while being These medications have different active ingredients and they belong to different groups of drugs. But certain choices and habits accelerate the process. To see a side-by-side comparison of Prolia and Fosamax, view this drug article. For a basic overview of Prolia, including details about its uses, see this article. Musculoskeletal pain from Prolia is mild or manageable for most people. By stopping RANKL from binding to its receptor Prolia reduces bone breakdown, bone loss, bone pain, and other bone complications. And theyll recommend if its the best option for your condition. For this reason, some calcium supplements are combined with vitamin D. This vitamin is available in two forms, vitamin D 2 (ergocalciferol) and vitamin If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Prolia injections administered by a healthcare professional. You do not give Prolia to yourself. What are the possible side effects of Prolia? Below, we answer some common questions about taking Prolia. Our website services, content, and products are for informational purposes only. Prolia is a RANKL inhibitor. Learn more about your health after menopause. You might wonder how Prolia and the drug Xgeva compare. 12 Low serum calcium levels should be corrected before starting denosumab; supplemental calcium and vitamin D is required in patients predisposed to hypocalcaemia (see Ensure adequate calcium and vitamin D intake ). And be sure to let your doctor know about all the medications youre currently taking. Rare, long-term side effects of Prolia include fractures of the spine or femur (thighbone). Denosumab (Prolia) for postmenopausal osteoporosis Allergic reaction. They have some similar uses and side effects, but they also have some differences. Prolia - Patient Information Leaflet (PIL) - (emc) - medicines You may need to have a negative pregnancy test before starting this treatment. Having dental procedures, including tooth extractions, during Prolia treatment may increase your risk of dental side effects. Osteoporosis treatment: Medications can help - Mayo Clinic Factors to consider include those in the list below. A few examples of bisphosphonates include: If youd like to know more about using a bisphosphonate for your condition, talk with your doctor. Youll receive Prolia doses from a healthcare professional. American Dental Association (ADA) recommendations say that tooth extractions are allowable if needed during Prolia treatment, if both you and your dentist agree. If you keep this medicine at home, store it in the original carton in a refrigerator. Prolia was the right choice for me because it worked for me and it was 1 shot every 6 months. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed. Nonmetastatic means the cancer hasnt spread to other areas of the body. You should not receive Prolia if you are allergic to denosumab, or if you have: low levels of calcium in your blood (hypocalcemia); or; if you are pregnant. If you have serious side effects from Prolia, call your doctor right away. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Prolia is sometimes used in people whose bone fracture is caused by certain medicines or cancer treatments. Here are a few questions to consider asking your doctor: You can also learn more about osteoporosis treatment options here. (With off-label use, a drug is used to treat conditions other than those its been approved to treat.) * Approximation only. If you have more questions about what to expect with dental procedures while youre taking Prolia, talk with your doctor or dentist. If your doctor says this is safe for you, youll be shown how to inject the medication. But theyre each effective in treating osteoporosis and preventing bone loss. Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. that's no different than scheduling a visit to the dentist twice a year. They also include any added costs of the drug being given by a healthcare professional. Your FRAX score is your risk of having an osteoporosis-related fracture in the next 10 years. To prevent osteoporotic fractures, combined calcium and vitamin D supplementation is recommended at the correct dosage (1,0001,200 mg calcium and 800 IU of vitamin D per day). Supplementation should be targeted on vulnerable groups such as elderly and institutionalised people, patients with osteoporosis and individuals on glucocorticoids. Numerous trials have shown that calcium and vitamin D supplementation is effective and safe. In particular, no increased cardiovascular risk was observed. Prolia works by targeting a molecule called RANKL that osteoclasts need to work. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. If your levels are high, theyll typically recommend lifestyle changes and medication. Your risk of bone fractures can increase when you stop, skip or delay using Prolia. All subjects in the clinical trials of Prolia received 800mg of calcium and What's the difference between Prolia and Reclast? Policy. You may report side effects to FDA at 1-800-FDA-1088. They can suggest ways to help relieve these side effects. Prolia: Side Effects, Alternatives, How It's Administered, To learn about other mild side effects, talk with your doctor or pharmacist, or read Prolias medication guide. Discuss the foods you eat and the vitamins you take with your health care professional. Use of the term male in this article refers to sex assigned at birth. With peripheral edema, fluid builds up in your body and causes swelling in your arms and lower legs. Do not use denosumab if you are pregnant. You may wonder how Prolia compares to the medication Zometa. You may take the carton out of the refrigerator and allow it to reach room temperature before the injection is given. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Osteoporosis Is Common in Older Men, Know the Risks, Your Guide to Osteoporosis and Broken Bones: Know Your Risks, 7 Things You Can Do Today to Prevent Osteoporosis, treat osteoporosis in males* and in females* whove gone through, treat osteoporosis caused by long-term use of, increase bone mass in females using certain, increase bone mass in males using certain treatments for, increased risk of bone fracture after stopping Prolia treatment, such as having multiple, severe pain in your joints, bones, and muscles, skin-related side effects, such as rash, dry skin, or blisters, decreased bone production, which means your bones take longer to make new bone tissue, dental problems and jaw-related side effects*, jaw necrosis (death of tissue in the jawbone), Prolias active ingredient is denosumab. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. High cholesterol itself doesnt cause any symptoms. Theyre commonly used to treat osteoporosis. low calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes). All rights reserved. We study millions of patients and 5,000 more each day. But they each work differently because Prolia is a monoclonal antibody (it may also be called a miscellaneous bone resorption agent) and Reclast is a bisphosphonate which means they have different side effects, other uses, tolerability, and effectiveness profiles. But its not clear whether this side effect occurred in clinical studies. We do not endorse non-Cleveland Clinic products or services. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Copyright 1996-2023 Cerner Multum, Inc. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives. If the side effects seem life threatening or you think youre having a medical emergency, immediately call 911 or your local emergency number. generic drugs) are not considered. So be sure to tell your doctor about all your health conditions before taking Prolia. In addition, Prolia may also be used off-label for other conditions that cause bone loss or loss of bone mineral density. * For more information about this side effect, see Side effect specifics below. Your risk for some health conditions increases when you are postmenopausal. These supplements help to prevent a low calcium level while youre taking Prolia. Results may vary. If youre able to become pregnant, your doctor will order a pregnancy test for you before you take Prolia. The most common side effects of Prolia in patients with corticosteroid-induced osteoporosis are back pain, high blood pressure, lung infection (bronchitis), and headache. Healthline Media does not provide medical advice, diagnosis, or treatment. Theyll do this with certain tests, such as a bone scan or ultrasound. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia. Dizziness from Prolia is usually mild and may go away on its own within a few days or weeks. Osteoporosis Prolia is also available in a biosimilar form. Prolia is a prescriptionmedicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments for breast cancer that has not spread to other parts of the body. Prolia improves bone mass and increases bone mineral density. It may not cover all possible information. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. (2021). In addition, you should use effective birth control while youre taking Prolia. Ask your doctor about your own risk. Constipation was also reported as a side effect in females using Prolia for osteoporosis. Others may continue for as long as you take the drug, but they can be easily managed. Before taking Prolia, tell your doctor about all of your medical conditions, including if you: Your healthcare provider should do a pregnancy test before you start treatment with Prolia. Your doctor may suggest limiting foods that are high in trans fats, such as fried foods. DENOSUMAB (den oh sue mab) slows bone breakdown. Follow your doctor's instructions. But Zometa contains the active drug zoledronic acid. Prolia isnt approved to treat osteopenia or arthritis. Ask your plan if they cover the drug, and what the cost will be for you. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Motion sickness, nausea, and vomiting can occur as a part of vertigo. These side effects include: Your risk for these serious side effects may be higher if youre older and have certain dental procedures. (To learn more, see the Side effect specifics section above.). Get the treatment that fits your lifestyle, Stay informed with courtesy reminders, recipes and so much more. Symptoms can be mild or serious and can include: For mild symptoms of an allergic reaction, call your doctor right away. What should I know about Prolia vs. Boniva? Last medically reviewed on November 29, 2022. Starting an osteoporosis drug? Here If you drink alcohol, talk with your doctor about how much is safe to drink with your condition. Other side effects may continue for as long as you receive the medication, but they can often be relieved with other treatments. But some females* who received Prolia for osteoporosis after menopause had to stop Prolia treatment due to back pain. A healthcare provider will give you this injection in a hospital or clinic. You should also talk with them if you have any serious side effects during Prolia treatment. Monoclonal antibodies are made to target and destroy only certain cells in the body. Be sure to read this information carefully each time. They may want to check for other causes. All information is observation-only. Tell your doctor if you become pregnant. Can diet help improve depression symptoms? You might like to know how Prolia and the drug Evenity compare. Some rare side effects of Prolia can be serious and need medical attention. But nausea may be a symptom of side effects such as vertigo or constipation. Learn about the highest quality calcium supplements here. You should also talk with your doctor if you have nausea during treatment. Do not take this medicine with any of the following medications: This medicine may also interact with the following medications: This list may not describe all possible interactions. NOTE: This medicine is only for you. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Side effects are possible with Prolia use, but in most cases they go away after a while. They can also suggest ways to relieve this side effect. Although both drugs are approved to treat similar conditions, they work in different ways. Before starting Prolia treatment, talk with your doctor about any tooth procedures you have scheduled. These are serious. You will receive your Prolia injection from your healthcare provider at a their office or clinic. Your doctor can provide more information to you about the benefits and risks of using Prolia for your condition. The drug attaches to the RANK protein and helps prevent osteoclasts from breaking down bone. Forteo is given as a self-injection once daily. You should not receive Prolia if you are allergic to denosumab, or if you have: low levels of calcium in your blood (hypocalcemia); or. Prolia To learn how Prolia and Tymlos are alike and different, see this comparison. Nausea can sometimes be a symptom of severe constipation. Prolia pregnancy and breastfeeding warnings. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. Had parathyroid or thyroid surgery (glands located in your neck), Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome), Have kidney problems or are on kidney dialysis, Are taking medicine that can lower your blood calcium levels, Plan to have dental surgery or teeth removed, Are breast-feeding or plan to breast-feed. If you have low calcium levels, you should not take Prolia. Any advice? Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Women going through menopause have a higher risk of developing osteoporosis. Studies have found that Prolia is generally safe and effective to treat osteoporosis and certain types of bone loss. This was one of the most common side effects in clinical trials of females who received Prolia for osteoporosis after menopause. Common side effects of Prolia can vary depending on which condition the drug is being used to treat. (Biologic medications are made from living organisms.). Use effective birth control while using denosumab and for at least 5 months after your last dose. With arthritis, you have pain and inflammation of your joints. If youve already gone through menopause, your risk for bone loss is increased. This medication guide provides information about the Prolia brand of denosumab. Prolia Prolia (denosumab) injection, for subcutaneous use. This list doesnt include all possible mild side effects of the drug. Your body needs calcium to build and maintain strong bones. Your heart, muscles and nerves also need calcium to function properly. Some studies suggest that calcium, along with vitamin D, may have benefits beyond bone health: perhaps protecting against cancer, diabetes and high blood pressure. Call your doctor right away if you have an allergic reaction to Prolia. For example, if you have a serious UTI or other infection, call your doctor right away. You should talk with your doctor if you develop any mild side effects that concern you. Osteoporosis is a condition that weakens your bones, making them more susceptible to fractures. Call your doctor or health care professional if you are unable to keep an appointment. This can cause your weight to change and may explain any weight gain since starting Prolia treatment. The fractures may require surgeries, take several months to heal, or both. You might be interested in seeing how Prolia and the drug Boniva compare. Theyll discuss with you other treatments to help prevent bone loss. If you develop high cholesterol with Prolia, your doctor can guide you on which treatment options are right for your condition. For more information about the uses of Prolia, see the Is Prolia used for osteoporosis? and Is Prolia used for other conditions? sections below. Usually, but it depends. for prostate cancer that has not spread to other parts of the body. For more information about how Prolia and Zometa compare with each other, see this article. What should I know about Prolia vs. Fosamax? But weight gain may occur with other medications you take or other health conditions you have. Prolia and Forteo are both used to treat osteoporosis. If the user is trying to grow bone due to osteoporosis, osteopenia, or any reason, the recommended intake is 4 capsules divided into 2 doses also taken in the morning and evening with food. pain in bones and muscles, including back, arm, and leg pain, pain or swelling in the thigh or groin area. Prolia has active ingredients of denosumab. Learn more about the FRAX score and the treatment options for, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. To learn more about this, see the How is Prolia administered? section below. If youd like more information about Prolia use during pregnancy or while breastfeeding, talk with your doctor. But this isnt the case with Prolia. Brush and floss your teeth regularly. Every 6 months youll get another dose of Prolia. Pregnancy. But Prolia is given once every 6 months by a healthcare professional. Xgeva is another brand of denosumab that treats high calcium levels caused by cancer and prevents bone breaks. Tell your doctor if you become pregnant. Certain side effects of Prolia that may last longer than others include: Ask your doctor about serious or long-lasting side effects of Prolia and what you should know before starting this drug. Some research has shown that alcohol consumption may increase your risk of osteoporosis, a bone fracture or impaired healing after a fracture. Certain kidney problems, such as chronic kidney failure, can cause a low calcium level in your blood. 1 shot every 6 months could mean fewer doses. This includes proper brushing, flossing, mouthwash use, and regular professional dental cleanings. Examples of conditions Prolia is used off-label to treat include: Prolia is one option available to treat osteoporosis and reduce bone loss in people with a high risk for bone fracture. Instead, your doctor may recommend that you make certain changes to your diet, such as increasing your calcium and vitamin D intake. Stopping some drugs leads to withdrawal symptoms because your body is used to the drug and needs it for you to feel normal. Bisphosphonates, on the other hand, help increase bone thickness and prevent bone breakdown. Your doctor should examine your mouth before you start Prolia and may tell you to see your dentist. Theyll also usually treat the hypocalcemia right away. These articles might help: Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. And they want you to get the best care possible. Learn more about the unique risk factors for osteoporosis in, Osteoporosis weakens bones, which leads to breaks in the hips, wrists, and spine. Coral calcium is also used in maxillofacial surgery and bone grafting. Will my fracture risk come back if I stop Prolia treatment? (Biosimilars are like generic drugs. Like most drugs, Prolia may cause mild or serious side effects. It could harm the unborn baby or cause birth defects. But if you look at D3 supplements online, youll see that most commercial supplements have higher doses usually either 1,000, 2,000, 5,000 or 10,000 IU. It is important not to miss your dose. Prolia may lower the level of calcium in your blood. Its a, Forteos active ingredient is teriparatide. These can include tingling or numbness in the hands, feet, and face. Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments for prostate cancer that has not spread to other parts of the body. Talk with your doctor about your health history and discuss your risks with Prolia treatment. Doing so will help you avoid the risk for a low calcium level during treatment. Cleveland Clinic is a non-profit academic medical center. Treating any mouth or dental problems early is the best way to help prevent serious dental complications.